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產(chǎn)品名稱:
Darinaparsin
產(chǎn)品型號(hào):
MD819869
產(chǎn)品展商:
晶欣生物
產(chǎn)品文檔:
無相關(guān)文檔
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Darinaparsin
Cat.Not：MD819869
prices：5MG 1800
10MG 2800
Speciication
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 µM, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 µM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. [2] Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.[1]
Chemical Properties
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Cas No.
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69819-86-9
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SDF
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別名
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Dimethylarsinic glutathione
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化學(xué)名
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L-γ-glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine
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Canonical SMILES
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OC(CNC([C@H](CS[As](C)C)NC(CC[C@H](N)C(O)=O)=O)=O)=O
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分子式
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C12H22AsN3O6S
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分子量
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411.3
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溶解度
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0.1mg/mL in ethanol and DMF, 10mg/mL in DMSO
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儲(chǔ)存條件
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Store at -20°C
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General tips
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For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
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Shipping Condition
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Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Chemical Structure
